Pushing The Limits Introducing 1-MNA: The New Longevity Molecule With Lisa Tamati
In this episode, we delve into a revolutionary longevity molecule that you might not have heard of before: 1-MNA. If you're interested in staying younger longer and if you want to maintain your energy and vitality then this is an episode for you.
Perhaps you have read the groundbreaking book by Dr David Sinclair "Lifespan" where he talks about NAD and how crucial it is for the body and how it can help upregulate sirtuin genes (longevity genes) and help you maintain your cellular health and energy. We are now 4 years on we have more data, studies and information to share in this arena.
Perhaps you have been trying to improve your NAD metabolism, taking NMN (nicotinamide mononucleotide) or NR (nicotinamide riboside), and upregulating sirtuin genes, if you have then you need to hear this.
We'll explore the intricacies of NAD pathways, the role of key enzymes, and why simply supplementing with NAD precursors may not be the best holistic approach and how we can improve on that approach to anti-aging
Key Points Discussed:
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Introduction to NAD Metabolism:
- Overview of previous episodes on NAD metabolism with experts like Professor Joseph Baur, Dr. Elizabeth Yurth from the Boulder Longevity Institute, and Dr. Elena Seranova.
- Importance of understanding the complexities of NAD pathways beyond the basics.
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Understanding 1-MNA:
- Explanation of 1-MNA and its role in controlling NAD levels by blocking the enzyme NNMT (Nicotinamide N-methyltransferase).
- The dangers of upregulating NNMT, which degrades NAD and can lead to various health issues.
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Key Enzymes in NAD Metabolism:
- Discussion on the salvage pathway and two critical enzymes that degrade NAD.
- Importance of regulating NNMT to prevent its deleterious effects, particularly in senescent cells, cancer cells, and fat cells.
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Benefits of 1-MNA
- How 1-MNA can help maintain a balanced NAD metabolism by inhibiting NNMT.
- Potential benefits for conditions like schizophrenia, neurodegeneration, liver diseases, and cancer.
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Research and Studies:
- Overview of studies showing the positive effects of 1-MNA on post-COVID conditions, inflammation, and mitochondrial function.
- Insights from animal studies on 1-MNA's protective effects against metabolic disorders.
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Practical Applications:
- Recommendations for integrating 1-MNA into supplement regimens, especially for those taking NMN or NR.
- Potential benefits for various conditions, including obesity, metabolic syndrome, cardiac disease, liver disease, cancer risk, long COVID, and fatigue.
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Balancing NAD Levels:
- Importance of maintaining NAD levels for energy production, DNA repair, neurotransmitter health, and longevity.
- The role of NAD as a redox molecule and the balance between NAD+ and NADH.
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Conclusion:
- Encouragement to explore further research on NNMT and its impact on health.
- Final thoughts on the potential of 1-MNAas a crucial supplement for maintaining NAD balance and promoting longevity.
References and Links:
- Boulder Longevity Institute: https://boulderlongevity.com/
- SSRP Institute: https://ssrpinstitute.org/
- Studies on NNMT and related conditions: Research
- If you enjoyed this episode, please give it a like, share, and subscribe to the YouTube channel.
- Tune in weekly for more interviews with top doctors and scientists on health optimization and longevity.
If you want to start supplementing with 1-MNA to support your own healthy aging journey, to upregulate your NAD metabolism, support sirtuin genes and prevent the overexpression of the deleterious NNMT Enzyme you can buy it here: 1-MNA and use code NAD to get $25 off your first order
- Stay up-to-date with the latest research and evolve with the science to optimize your health and longevity. See you in the next episode!
Personalised Health Optimisation Consulting with Lisa Tamati
Lisa offers solution focused coaching sessions to help you find the right answers to your challenges.
Topics Lisa can help with:
Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach.
She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking.
She has extensive knowledge on such therapies as hyperbaric oxygen, intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing.
Testing Options
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Comprehensive Thyroid testing
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DUTCH Hormone testing
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Adrenal Testing
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Organic Acid Testing
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Microbiome Testing
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Cell Blueprint Testing
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Epigenetics Testing
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DNA testing
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Basic Blood Test analysis
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Heavy Metals
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Nutristat
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Omega 3 to 6 status
and more
Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine .
She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. Book your consultation with Lisa
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Introducing PerfectAmino
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Listen to the episode with Dr Minkoff here:
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To pushing the limits,
Lisa and team