ThePrint ThePrintPod: Lean diabetes triggers more serious insulin deficiency, higher risk of heart disorders in Indians
Aug 22, 2025
Explore the unique phenomenon of lean diabetes, particularly in South Asians, where low BMI leads to serious insulin deficiency. Discover how this subtype poses a greater risk for heart disorders due to severe beta-cell dysfunction. The discussion highlights the challenges in diagnosing and treating lean diabetes, emphasizing the need for personalized management strategies. This fascinating look at a specific health issue sheds light on the complexities of diabetes beyond the conventional understanding.
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Distinct Metabolic Profile Of Lean Diabetes
- Lean diabetes shows earlier onset, worse beta-cell dysfunction, and higher microvascular risk than typical type 2 diabetes.
- It often occurs with BMI <18.5 and less insulin resistance, especially in South Asians.
Current Classification Misses Atypical Cases
- MDRF researchers reported severe beta-cell dysfunction and relatively less insulin resistance in lean diabetes.
- Current classification systems often fail to categorize this atypical phenotype properly.
Socioeconomic And Early-Life Drivers
- Lean diabetes is common in South Asians and appears in people in their 40s and 50s who look lean.
- Childhood undernutrition, poor diets and genetics may contribute, affecting lower socioeconomic groups.