OncLive® On Air S13 Ep42: Endometrial (Uterine) Cancer 2025 UPDATE
Aug 11, 2025
Discover the latest insights on uterine and endometrial cancer! The hosts discuss abnormal vaginal bleeding as a key symptom and explore various risk factors, including obesity and genetic syndromes. They dive into the critical role of endometrial biopsy and staging classifications. Learn about surgery as the primary treatment and the tailored adjuvant therapy recommendations. The conversation also highlights emerging therapies such as molecular profiling and immunotherapy, along with management strategies for rare uterine sarcomas.
AI Snips
Chapters
Transcript
Episode notes
Postmenopausal Bleeding Is Highly Suspicious
- Vaginal bleeding in a postmenopausal woman should prompt an endometrial biopsy because ~90% of endometrial cancers present this way.
- Other symptoms include discharge, pelvic pain/pressure, and bowel habit changes which warrant evaluation.
Screen For Hormonal And Genetic Risks
- Assess hormone and genetic risk factors like obesity, estrogen exposure, tamoxifen, PCOS, prior pelvic radiation, and endometrial hyperplasia.
- Offer prophylactic hysterectomy at ~age 35 for women with Lynch syndrome after childbearing is complete.
Staging And Histology Guide Prognosis
- Stage definitions: stage 1 confined to corpus, stage 2 extends to cervix, stage 3 regional spread, stage 4a invades bladder/rectum, 4b distant disease.
- About 80% are endometrioid; grade 1–2 are type 1, while serous/clear cell/grade 3 are type 2 and more aggressive.