Best of (Nobel Prize Edition) - Katalin Karikó and Drew Weissman: The Vaccine Revolution

The COVID-19 vaccine came out at warp speed because of the work of these two scientists. This week, they were awarded the Nobel Prize in Physiology or Medicine. In celebration, we are re-posting our episode about Katalin Karikó and Drew Weissman. For many, many years they investigated the secrets of messenger RNA (mRNA). And when the pandemic began, their research was ready and waiting. On this episode you’ll hear Katalin Karikó talk about her humble beginnings in Hungary, and the forces that enabled her to persevere, even though for decades people thought her ideas about mRNA were laughable.  She was denied grants, lost jobs and wasn’t taken seriously, but she never wavered. Fortunately, she met Drew Weissman one day at a copy machine, where they both worked at the University of Pennsylvania. Dr. Weissman was an immunologist, working on a vaccine for HIV.  He was interested in Karikó’s work and they began to collaborate. Even when they made major discoveries, they could not get support for their work… until the Corona Virus appeared. Now the scientific world sees the potential that Karikó and Weissman saw all along: that mRNA may open the door to many other vaccines and to therapeutic treatment for a host of illnesses, from Cancer to Sickle Cell Anemia to Heart Disease.  

(c ) American Academy of Achievement 2023