In this episode, we have the honor of speaking with Professor John Myburgh, a former South African physician and researcher who has dedicated his life to improving the field of critical care medicine. Professor Myburgh has made significant contributions to the field of fluid resuscitation, catecholamines, and microbiomes. In this episode, we will be discussing his early years in medicine, some reflections on medicine in South Africa and how his experiences have shaped his research interests. We will also delve into the latest research on fluid resuscitation, catecholamines, and microbiomes. So sit back, relax, and enjoy this fascinating conversation with Professor John Myburgh. Further Reading: SAFE TBI: Cooper DJ, Myburgh J, Heritier S, et al. Albumin resuscitation for traumatic brain injury: is intracranial hypertension the cause of increased mortality?. J Neurotrauma. 2013;30(7):512-518. doi:10.1089/neu.2012.2573 SAFE Study: Finfer S, Norton R, Bellomo R, Boyce N, French J, Myburgh J. The SAFE study: saline vs. albumin for fluid resuscitation in the critically ill [retracted in: Mayr W, Prowse C. Vox Sang. 2004 Aug;87(2):142]. Vox Sang. 2004;87 Suppl 2:123-131. doi:10.1111/j.1741-6892.2004.00468.x CHEST Study: Myburgh JA, Finfer S, Bellomo R, et al. Hydroxyethyl starch or saline for fluid resuscitation in intensive care [published correction appears in N Engl J Med. 2016 Mar 31;374(13):1298]. N Engl J Med. 2012;367(20):1901-1911. doi:10.1056/NEJMoa1209759 PLUS study: Finfer, S., Micallef, S., Hammond, N., Navarra, L., Bellomo, R., Billot, L., ... & Myburgh, J. (2022). Balanced multielectrolyte solution versus saline in critically ill adults. New England Journal of Medicine, 386(9), 815-826. CAT study: Myburgh JA, Higgins A, Jovanovska A, Lipman J, Ramakrishnan N, Santamaria J, CAT Study Investigators. A comparison of epinephrine and norepinephrine in critically ill patients. Intensive care medicine. 2008 Dec;34:2226-34. SOAP II Trial: De Backer D, Biston P, Devriendt J, Madl C, Chochrad D, Aldecoa C, Brasseur A, Defrance P, Gottignies P, Vincent JL. Comparison of dopamine and norepinephrine in the treatment of shock. New England Journal of Medicine. 2010 Mar 4;362(9):779-89. Prof. Myburg on Catecholamines at SMACC/CODA: https://youtu.be/90ru25QuGFI