Soon individual genome sequences will be a standard part of health records, which will revolutionise biomedical discovery, personal healthcare, and health system management. Millions of genome sequences integrated with millions of clinical records and other information from personal devices and the internet of things will create a multi-dimensional data ecology that will require advanced systems not only to secure the privacy and provenance of the data, but also to enable its analysis by machine learning and artificial intelligence. The last of the great cottage industries will become the most important of the data-intensive industries of the 21st century. Hear more on what the future holds from Professor John Mattick, Garvan Institute of Medical Research. Held as part of Sydney Ideas on 21 November http://sydney.edu.au/sydney_ideas/lectures/2017/21st_century_medicine_2017.shtml