Explore the association between maternal hemoglobin concentration and pregnancy outcomes, discuss the potential of a maternal vaccine for preventing Group B-Streptococcus, examine the impact of a GBS vaccine in reducing antibiotic usage in the NICU, study high altitude simulation testing in children with ventilatory pulmonary disorders, and delve into Disney's investment in solving BPD and the FDA approved vaccine for RSV.
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Quick takeaways
Preterm infants with more severe neonatal courses are more likely to develop hypoxemia during high altitude simulation testing (HAST).
Infants who were not on respiratory support at 36 weeks had a higher likelihood of passing HAST.
Deep dives
Preterm infants at risk of hypoxemia during air travel
Commercial air travel at high altitudes poses a risk of hypoxemia for preterm infants, especially those with bronchopulmonary dysplasia (BPD). These infants may fail hypoxemia challenge testing (HAST), making it difficult to determine if it is safe for them to fly. Previous studies have shown that preterm infants with BPD are likely to fail HAST. The study aims to determine the likelihood of developing hypoxemia during HAST over time and to identify neonatal risk factors associated with hypoxemia.
Results of Hypoxemia Challenge Testing in Preterm Infants with BPD
The study included preterm infants born at or before 34 weeks of gestation with BPD. The infants underwent high altitude simulation testing (HAST) to assess their risk of hypoxemia during air travel. The results showed that infants with more severe neonatal courses, including longer duration of respiratory support, greater support at 36 weeks, and pulmonary hypertension, were more likely to develop hypoxemia during HAST. The probability of passing the HAST increased over time, but even at 24 months corrected, some infants still experienced hypoxemia.
Implications for Air Travel and Neonatal Risk Factors
The findings have implications for determining fitness to fly and managing hypoxemia in children born prematurely. Infants who were not on respiratory support at 36 weeks were more likely to pass HAST. The severity of BPD, history of pulmonary hypertension, use of postnatal steroids, and discharge on respiratory support were associated with a lower likelihood of passing HAST. The study provides important information for healthcare professionals and parents of preterm infants with BPD who are considering air travel.
As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.
Enjoy! _____________________________________________________________________________________ Show notes and articles can be found on our website: http://www.the-incubator.org/142/
As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.
Enjoy!
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