TWiV 1222: Clinical update with Dr. Daniel Griffin
May 31, 2025
Dr. Griffin discusses critical vaccination policy shifts, focusing on new recommendations for children and pregnant women. Concerns arise over misinformation and legislative changes affecting vaccine exemptions in Texas. The conversation touches on the global measles outbreak and recent COVID-19 statistics. Highlights include the importance of updated vaccination strategies and the role of respiratory pathogens. The impact of COVID-19 on child health, including post-infection complications, is emphasized, alongside insights on PPE usage among healthcare providers.
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insights INSIGHT
Political Override of Vaccine Policy
Removing COVID-19 vaccine recommendation for children and pregnant women bypassed the normal scientific advisory process.
This political decision risks reducing vaccine coverage and insurance coverage, potentially increasing preventable child deaths.
insights INSIGHT
Child COVID Death Toll and Vaccines
Over 2,000 U.S. children have died from COVID-19, mostly unvaccinated and many under four years old.
Vaccine-preventable COVID hospitalization and death in children remain significant despite public perception of low risk.
insights INSIGHT
Widespread Vaccine Hesitancy Risks
About 20% of Americans refuse COVID vaccination for themselves or children, a dangerously high rate.
This vaccine hesitancy deepens health disparities and increases preventable deaths and community risk.
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In his weekly clinical update, Dr. Griffin with Vincent Racaniello discusses vaccination trends, the changes COVID-19 vaccine recommendations for children and pregnant women, easing of vaccination exemptions in Texas, the ongoing measles outbreak globally before Dr. Griffin reviews recent statistics on RSV, influenza and SARS-CoV-2 infections the Wasterwater Scan dashboard, whether or not the NB.1.8.1 should be included in the fall 2025 vaccines and concern as confirmed diagnosis of COVID-19 rise here and in China, different mechanisms by which to reduce transmission of respiratory pathogens, the May 22 VRBPAC COVID-19 vaccine meeting, where to find PEMGARDA, prolonged steroid and antibiotic therapies, provides information for Columbia University Irving Medical Center’s long COVID treatment center, where to go for answers to your long COVID questions, how spike protein may alter mast cells and the immune response and contacting your federal government representative to stop the assault on science and biomedical research.
A pilot study of coughing into the shirt to disrupt respiratory pathogen transmission (International Journal of Emergency Medicine)
Hybrid B- and T-Cell Immunity Associates With Protection Against Breakthrough Infection After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination in Avon Longitudinal Study of Parents and Children (ALSPAC) Participants (JID)
FDA panel is split on updates to COVID shots as questions loom for fall vaccinations(AP News)
COVID-19 Vaccines (2025-2026 Formula) for Use in the United States Beginning in Fall 2025(FDA)
Interim Clinical Considerations for Use of COVID-19 Vaccines in the United States (CDC: COVID-19)
Clinical effectiveness of oral antiviral treatment for non-hospitalized high-risk patients with COVID-19 during Omicron JN.1 subvariant wave(Pneumonia)
Drug interaction checker (University of Liverpool)
A Systematic Review and Meta-analysis of the Effectiveness of Remdesivir to Treat Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Patients (CID)
Spike proteins of coronaviruses activate mast cells for degranulation via stimulating Src/PI3K/AKT/Ca2+ intracellular signaling cascade (Journal of Virology)
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