The Network State Podcast #35 - Noor Siddiqui
Jan 16, 2026
Noor Siddiqui, founder of Orchid, pioneers in whole-genome embryo screening for genetic diseases. They discuss the evolution from biological chance to choice and how societal perceptions of embryo screening are changing. Noor highlights the clinical importance of early genetic screening in preventing severe health conditions. The conversation also touches on the evolving political landscape surrounding technology and reproduction, emphasizing the need for compassion in bioethical discussions.
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Whole-Genome Embryo Screening
- ORCHID sequences an embryo's whole genome from a five-cell biopsy to detect thousands of diseases early.
- This gives actionable information at the embryo-selection stage rather than waiting until after birth.
Chromosome Tests Versus Base-Level Reads
- Traditional embryo testing mainly detects chromosome-level errors (missing/extra chapters).
- Whole-genome sequencing reads every base, revealing small variants that cause many monogenic diseases.
Maximize Information For IVF Parents
- If parents already choose IVF, offer them the maximum genetic information available during embryo selection.
- Use the added data to transfer unaffected embryos when possible.
