Phoenix Sepsis Criteria with Dr. Nelson Sanchez-Pinto Part 1

Feb 19, 2024

Dr. Nelson Sanchez-Pinto, an expert in pediatric sepsis criteria and diagnosis, discusses the limitations of prior pediatric sepsis definitions and the rationale for creating the Phoenix Sepsis Criteria. The podcast explores the methodology of deriving the criteria, analyzing diverse patient outcomes, developing a composite model for mortality risk estimation in infected patients, and introducing the Phoenix eight organ system score for research and management purposes.

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Introduction

00:00 • 4min

Developing a Data-Driven Criteria for Pediatric Sepsis

04:04 • 20min

Inclusion of Diverse Patients in Analysis of Mortality Outcomes

24:23 • 3min

Development of a Composite Model for Estimating Mortality Risk in Patients with Infection

27:36 • 3min

Exploring the Development of Sepsis Criteria Models

31:02 • 3min

L. Nelson Sanchez-Pinto, MD, is a Pediatric intensivist at Lurie Children’s Hospital of Chicago, where he is also an Associate Professor of Pediatrics at Northwestern University Feinberg School of Medicine.

Dr. Sanchez-Pinto co-led an international group of researchers in the Society of Critical Care Medicine Pediatric Sepsis Definition Task Force for the Development and Validation of the new Phoenix Criteria for Pediatric Sepsis and Septic Shock that was featured at the 2024 SCCM conference.

Learning Objectives:

By the end of this podcast, listeners should be able to discuss:

The limitations of prior definitions of pediatric sepsis and the rationale for creating the Phoenix Sepsis Criteria.
The methods and key outcomes used for deriving the Phoenix Sepsis Criteria.
How to diagnose sepsis using the Phoenix Sepsis Criteria.
General limitations of the Phoenix Sepsis Criteria.
Next steps in implementing the Phoenix Sepsis Criteria and the direction it provides for future research.

References:

Sanchez-Pinto LN, Bennett TD, DeWitt PE, et al. Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock. JAMA. Published online January 21, 2024. doi:10.1001/jama.2024.0196

Schlapbach LJ, Watson RS, Sorce LR, Argent AC, Menon K, Hall MW, Akech S, Albers DJ, Alpern ER, Balamuth F, Bembea M, Biban P, Carrol ED, Chiotos K, Chisti MJ, DeWitt PE, Evans I, Flauzino de Oliveira C, Horvat CM, Inwald D, Ishimine P, Jaramillo-Bustamante JC, Levin M, Lodha R, Martin B, Nadel S, Nakagawa S, Peters MJ, Randolph AG, Ranjit S, Rebull MN, Russell S, Scott HF, de Souza DC, Tissieres P, Weiss SL, Wiens MO, Wynn JL, Kissoon N, Zimmerman JJ, Sanchez-Pinto LN, Bennett TD; Society of Critical Care Medicine Pediatric Sepsis Definition Task Force. International Consensus Criteria for Pediatric Sepsis and Septic Shock. JAMA. 2024 Jan 21. doi: 10.1001/jama.2024.0179. Epub ahead of print. PMID: 38245889.

Richesson RL, Smerek MM, Blake Cameron C. A Framework to Support the Sharing and Reuse of Computable Phenotype Definitions Across Health Care Delivery and Clinical Research Applications. EGEMS (Wash DC). 2016 Jul 5;4(3):1232. doi: 10.13063/2327-9214.1232. PMID: 27563686; PMCID: PMC4975566.

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Thank you for listening to this episode of PedsCrit. Please remember that all content during this episode is intended for educational and entertainment purposes only. It should not be used as medical advice. The views expressed during this episode by hosts and our guests are their own and do not reflect the official position of their institutions. If you have any comments, suggestions, or feedback-you can email us at pedscritpodcast@gmail.com. Check out http://www.pedscrit.com for detailed show notes. And visit @critpeds on twitter and @pedscrit on instagram for real time show updates.