Who Turned Up the Heat? Serotonin Syndrome, Neuroleptic Malignant Syndrome, and Malignant Hyperpyrexia

Today we’re going to break down three life-threatening syndromes that every CRNA, anesthesia provider, and healthcare professional should know: Serotonin Syndrome, Neuroleptic Malignant Syndrome (NMS), and Malignant Hyperthermia (MH).

Though these conditions are rare, their symptoms often overlap—making quick, accurate diagnosis and intervention critical. Garry and Terry take a deep dive into the causes, symptoms, physiology, and treatment protocols for each condition, while also sprinkling in their signature humor and real-world insights.

Here’s some of what we discuss in this episode:

🧠 Understanding the overlap and differences between serotonin syndrome, NMS, and MH

💊 Medication triggers to watch out for—from SSRIs to succinylcholine

🚨 Emergency symptoms that demand immediate action

🧬 The role of genetics and pharmacology in MH

👨‍⚕️ Real-world prevention and treatment strategies for anesthesia providers

 

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