Neurology Minute Lab Minute - Antiphospholipid Syndrome
Feb 24, 2025
Dive into the complexities of antiphospholipid syndrome, where key antibodies play a pivotal role. Discover vital testing methods necessary for accurate diagnosis. Learn how different assays can impact results and the influence of anticoagulants on testing. This insightful discussion is crucial for anyone wanting to understand this intricate condition.
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Antiphospholipid Antibodies
- Antiphospholipid syndrome involves antibodies like lupus anticoagulant, anticardiolipin, and antibeta-2 glycoprotein-1 antibodies.
- Testing for all three is crucial for accurate diagnosis, often using reflexive panels.
Lupus Anticoagulant Testing
- Lupus anticoagulant testing uses APTT and DRVVT assays based on different principles (contact activation and factor X activation).
- Inform your lab about any anticoagulants the patient is taking, as they can interfere with these assays.
Anticoagulant Interference
- Anticoagulants, especially DOACs and vitamin K antagonists, can affect lupus anticoagulant assay results.
- Ideally, send assays before starting anticoagulants; if impossible, inform the lab about any existing medications.