Dr. Francis Collins, the longest-serving director of the NIH and a pivotal figure in the Human Genome Project, discusses urgent health issues with health correspondent Selena Simmons-Duffin. They dive into the troubling rise of vaccine hesitancy driven by cultural tribalism and misinformation. Collins shares insights on the impact of the COVID-19 pandemic on American health and highlights health disparities that persist in the U.S. He also offers advice to his successor on navigating politically charged health topics.