ID:IOTS - Infectious Disease Insight Of Two Specialists 3: Clarifying Coagulase-Negative Staph
Aug 11, 2021
Dive into the world of coagulase-negative staphylococci and uncover their essential roles in infectious diseases. These bacteria, often overlooked, pose significant challenges, especially in vulnerable patients. The discussion highlights their unique characteristics, the complexities of lab identifications, and the rise of antibiotic resistance. Special focus is on managing prosthetic infections and the importance of source control. This insightful conversation underscores the need for heightened awareness and accurate diagnosis to tackle these subtle yet serious threats effectively.
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CoNS: A Diverse Low-Pathogen Group
- Coagulase-negative staphylococci (CoNS) are a heterogeneous group distinct from Staphylococcus aureus by coagulase testing.
- Most CoNS are low-pathogenic skin commensals but include exceptions that can cause disease.
That Familiar Microbiology Phone Call
- Callum describes the common clinical experience of receiving a blood-culture call about gram-positive cocci in clusters.
- The lab often warns clinicians they cannot yet differentiate S. aureus from coagulase-negative staph on initial gram stain.
Prosthetics Turn CoNS Pathogenic
- CoNS lack many virulence factors but are problematic when prosthetic material or devices are present.
- They cause indolent, biofilm-driven infections of joints, valves, pacemakers and lines.