TWiV 1146: Clinical update with Dr. Daniel Griffin

Sep 7, 2024

Dr. Daniel Griffin, a clinical expert in infectious diseases, shares critical insights on seasonal influenza vaccine recommendations and the global efforts surrounding polio vaccination campaigns. He discusses COVID-19 updates, including the use of convalescent plasma and when to administer steroids. The conversation also covers the complexities of long COVID management, highlighting the impact of vaccination on preventing long-term symptoms. Dr. Griffin emphasizes global health initiatives, such as securing mpox vaccines for Africa, to reduce food insecurity in affected regions.

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Intro

00:00 • 3min

Vaccine Supply Challenges and Global Efforts

02:53 • 5min

COVID-19 and Semaglutide Insights

07:38 • 7min

Navigating COVID-19 Vaccination and Long COVID Management

14:13 • 14min

Understanding PASK: A Clinical Perspective on Post-SARS-CoV Conditions

28:37 • 2min

Vaccines and Community Health Challenges

30:17 • 7min

In his weekly clinical update, Dr. Griffin discusses seasonal influenza vaccine recommendations from the CDC, polio vaccine campaign securing mpox vaccine for Africa, and donating to reduce food insecurity in mpox affected areas before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, when to use convalescent plasma, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, how fibrin drives thromboinflammation and neuropathology in COVID-19, and an evidence based approach to long COVID.

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Links for this episode

Recommendations for seasonal influenza prevention and vaccines (MMWR)
Gaza: poliovirus RNA in sewage water (Reuters)
Success of the polio vaccination campaign in Gaza (Reuters)
UNICEF-Gavi-WO-Africa CDC securing mpox vaccines (Gavi)
mpox vaccine tender (CIDRAP)
What about vaccines? (Bavarian Nordic)
Resolving food insecurity (UNICEF USA)
Semaglutide and the SELECT trial(Journal of the American College of Cardiology)
COVID-19 deaths (CDC)
COVID-19 national and regional trends (CDC)
COVID-19 variant tracker (CDC)
SARS-CoV-2 genomes galore (Nextstrain)
Where to get pemgarda (Pemgarda)
EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
CDC Quarantine guidelines (CDC)
Early phase of SARs-CoV-2 infection (COVID.gov)
NIH COVID-19 treatment guidelines (NIH)
Infectious Disease Society guidelines for treatment and management (ID Society)
Drug interaction checker (University of Liverpool)
Molnupiravir safety and efficacy (JMV)
Convalescent plasma recommendation for immunocompromised (ID Society)
What to do when sick with a respiratory virus (CDC)
When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
Managing healthcare staffing shortages (CDC)
Optimal duration of systemic corticosteroids treatment (OFID)
Steroids,dexamethasone at the right time (OFID)
Anticoagulation guidelines (hematology.org)
Does vaccination prevent long COVID (LANCET: Respiratory Medicine)
Fibrin drives thromboinflammation & neuropathology in COVID-19(Nature)
Postacute sequelae of COVID: an evidenced based approach, Dr. Daniel Griffin (OFID)
Letters read on TWiV 1146
Dr. Griffin’s COVID treatment summary (pdf)
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv