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Parmita Mishra — How to Think About Biology (EP.244)
Nov 28, 2024
Parmita Mishra, Founder and CEO of Precigenetics, dives into the fascinating world of precision medicine and epigenetics. She breaks down complex concepts like gene regulation and the epigenetic influences on conditions like male pattern baldness versus sickle cell anemia. Parmita also reflects on the importance of communication in science and the need for FDA reform to keep pace with innovative research. With inspiring insights about her journey and her family's impact on public health, she encourages a fresh perspective on biology and entrepreneurship.
01:30:55
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Quick takeaways
- Epigenetics highlights how environmental factors influence gene expression, opening avenues for personalized medicine tailored to individual profiles.
- The complexities of CRISPR technology underscore the ethical challenges and caution required in attempting to manipulate polygenic traits and conditions.
Deep dives
Understanding Epigenetics and Its Significance
Epigenetics is a crucial aspect of biology, distinguishing itself from traditional genetics by focusing on how genes are expressed rather than their mere sequence. This concept illuminates the dynamic nature of genes, suggesting that while an individual’s genetic code remains constant, varying external factors can influence how those genes manifest in different cells and conditions. For instance, the expression of genes can be compared to a switchboard, where environmental influences can turn certain genes on or off, affecting cellular behavior. This understanding opens up new avenues for personalized medicine, as recognizing these differences can ultimately lead to tailored treatments based on an individual's unique epigenetic profile.
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