After Skool The Myth of Low-Serotonin & Antidepressants - Dr. Mark Horowitz | After Skool
Aug 13, 2025
35:46
The Myth of Low-Serotonin & Antidepressants - Dr. Mark Horowitz
Dr. Mark Horowitz, MBBS PhD is a training psychiatrist and Clinical Research Fellow in Psychiatry North East London NHS Foundation Trust (NELFT) and an Honorary Clinical Research Fellow at UCL. He runs the Psychotropic drug Deprescribing Clinic in North East London NHS Foundation Trust. Mark completed a PhD in the neurobiology of depression and the action of antidepressants at the Institute of Psychiatry, Psychology and Neuroscience at King’s College London.
Dr. Horowitz is an Associate Editor of the journal Therapeutic Advances in Psychopharmacology. He co-authored the recent Royal College of Psychiatry guidance on ‘Stopping Antidepressants’, and his work has informed the recent NICE guidelines on safe tapering of psychiatric medications. He has written several papers about safe approaches to tapering psychiatric medications including publications in The Lancet Psychiatry, JAMA Psychiatry and Schizophrenia Bulletin.
Dr. Horowitz has an interest in rational psychopharmacology, the way in which psychiatric drugs are often mis-represented to the public and safely deprescribing these drugs.
To learn more about Dr. Mark Horowitz's work visit: https://markhorowitz.org/
Follow him on Twitter @markhoro
To learn more about Dr. Joanna Moncrieff's work visit: https://joannamoncrieff.com/
To learn more about coming off antidepressants safely visit: https://www.outro.com/
Link to study https://www.nature.com/articles/s41380-022-01661-0
0:00 - Intro
2:45 - Rise in Antidepressants
4:07 - Disease Centered Model
7:17 - Drug Centered Model
8:59 - What do Antidepressants Actually Do?
10:28 - Antidepressants vs. Placebo
13:59 - Withdrawal
18:10 - Misdiagnosis
19:19 - Helping People Off Antidepressants
23:25 - Hyperbolic Tapering
26:45 - What Needs to Change
Please consider supporting After Skool on Patreon https://www.patreon.com/AfterSkool
Visit our site at https://www.afterskool.net/
Check out the new After Skool prints! after-skool.creator-spring.com
Or send us an email at afterskool100@gmail.com
Please share, like, comment, subscribe and hit the notifications bell so you don't miss future videos. Thank you. Follow the podcast for new episodes. We cannot change the world. But we can change ourselves...and that will change the world. The goal of this podcast is to empower the individual and deliver profound ideas through art. Find After Skool on YouTube: https://www.youtube.com/@AfterSkool/videos Disclaimer: This podcast is an independent initiative inspired by the thought-provoking content of After Skool. It is created by a viewer who appreciates the depth of the ideas shared and wants to make them more accessible in an audio format. While every effort is made to preserve the essence of the original content, this is not an official After Skool production, nor is it affiliated with or endorsed by After Skool. All rights to the original material belong to After Skool. If you have any concerns regarding this podcast, please feel free to reach out.
Dr. Horowitz is an Associate Editor of the journal Therapeutic Advances in Psychopharmacology. He co-authored the recent Royal College of Psychiatry guidance on ‘Stopping Antidepressants’, and his work has informed the recent NICE guidelines on safe tapering of psychiatric medications. He has written several papers about safe approaches to tapering psychiatric medications including publications in The Lancet Psychiatry, JAMA Psychiatry and Schizophrenia Bulletin.
Dr. Horowitz has an interest in rational psychopharmacology, the way in which psychiatric drugs are often mis-represented to the public and safely deprescribing these drugs.
To learn more about Dr. Mark Horowitz's work visit: https://markhorowitz.org/
Follow him on Twitter @markhoro
To learn more about Dr. Joanna Moncrieff's work visit: https://joannamoncrieff.com/
To learn more about coming off antidepressants safely visit: https://www.outro.com/
Link to study https://www.nature.com/articles/s41380-022-01661-0
0:00 - Intro
2:45 - Rise in Antidepressants
4:07 - Disease Centered Model
7:17 - Drug Centered Model
8:59 - What do Antidepressants Actually Do?
10:28 - Antidepressants vs. Placebo
13:59 - Withdrawal
18:10 - Misdiagnosis
19:19 - Helping People Off Antidepressants
23:25 - Hyperbolic Tapering
26:45 - What Needs to Change
Please consider supporting After Skool on Patreon https://www.patreon.com/AfterSkool
Visit our site at https://www.afterskool.net/
Check out the new After Skool prints! after-skool.creator-spring.com
Or send us an email at afterskool100@gmail.com
Please share, like, comment, subscribe and hit the notifications bell so you don't miss future videos. Thank you. Follow the podcast for new episodes. We cannot change the world. But we can change ourselves...and that will change the world. The goal of this podcast is to empower the individual and deliver profound ideas through art. Find After Skool on YouTube: https://www.youtube.com/@AfterSkool/videos Disclaimer: This podcast is an independent initiative inspired by the thought-provoking content of After Skool. It is created by a viewer who appreciates the depth of the ideas shared and wants to make them more accessible in an audio format. While every effort is made to preserve the essence of the original content, this is not an official After Skool production, nor is it affiliated with or endorsed by After Skool. All rights to the original material belong to After Skool. If you have any concerns regarding this podcast, please feel free to reach out.
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