Oncology Brothers: Practice-Changing Cancer Discussions How to Approach to Endometrial Cancer from Community Oncology Perspective
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Oct 24, 2024 Dr. Shannon Westin, a leading Professor at MD Anderson Cancer Center, shares her expertise on endometrial cancer. She delves into the various histologies and the importance of molecular classification in treatment decisions. Listeners will learn about current strategies for early-stage and advanced cancers, including the role of surgery and the promising combination of chemotherapy and immunotherapy. The discussion also highlights the significance of Next-Generation Sequencing in personalizing treatment for patients, offering vital insights for healthcare professionals.
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Histology And Molecular Features Matter
- Endometrioid is the most common and usually lower grade while non-endometrioid histologies tend to be more aggressive.
- Molecular features like P53 mutations can make an endometrioid tumor behave aggressively and alter prognosis.
Tailor Preoperative Imaging To Histology
- For low-grade endometrioid tumors with minimal symptoms, proceed to surgery after biopsy rather than extensive imaging.
- Image patients with serous, clear cell, carcinosarcoma, or undifferentiated histologies before surgery to assess for advanced disease.
Molecular Classification Is Becoming Standard
- Routine molecular testing now includes POLE mutation, mismatch repair IHC, and P53 status to classify tumors.
- Molecular classification is being incorporated into staging and can inform risk though it's still evolving.