MCAT Basics (from MedSchoolCoach) Enzyme Kinetics, Inhibition, and Categorization
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Nov 12, 2024 Dive into the fascinating world of enzymes and their critical role in biological reactions. Explore how enzymes work as catalysts by lowering activation energy and learn about the lock-and-key and induced fit models. Master the Michaelis-Menten equation, which reveals insights on enzyme efficiency and substrate binding. Delve into different types of enzyme inhibition, such as competitive and non-competitive, and understand their effects on activity. Finally, uncover the six major types of enzymes and their biological functions with real-world examples.
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Enzymes Speed Up Without Changing Equilibrium
- Enzymes speed reactions by lowering activation energy without altering equilibrium product amounts.
- They accelerate forward and reverse rates but do not affect the thermodynamics of a reaction.
Two Enzyme-Substrate Models
- Lock and Key model depicts substrate fitting enzyme like a key in a lock.
- Induced Fit model involves substrate-induced conformational changes for binding.
Michaelis-Menten Describes Initial Velocity
- Michaelis-Menten equation relates initial reaction velocity to substrate concentration hyperbolically.
- Initial velocity refers to the reaction speed right when the process starts, not over time.