Mathematics and Cancer Therapy: Trachette Jackson interviewed by Lynn Brandon
Sep 19, 2021
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Trachette Jackson, a renowned mathematician in oncology, discusses optimizing cancer drug therapy through mathematical models. She shares her journey into mathematical biology and highlights the importance of diversity in research. The podcast also explores the pandemic's impact on scientific collaboration and ends with a casual Q&A session with the guest.
Mathematical oncology research focuses on data-driven models for cancer therapy optimization.
Mathematical models predict optimal dosing schedules and synergistic interactions in cancer therapy.
Deep dives
Research in Mathematical Oncology and Targeted Molecular Therapeutics
The podcast episode delves into the research of Trey Shet L. Jackson, a mathematics professor specializing in mathematical oncology. Jackson's work focuses on creating data-driven mathematical models for cancer, particularly in optimizing targeted molecular therapeutics. By integrating molecular events with cellular dynamics, including the tumor microenvironment, her research aims to enhance the understanding of tumor growth and response to therapies.
Impact of Mathematical Modeling in Cancer Therapy Advancements
The podcast highlights how mathematical models have influenced advancements in cancer therapy. Jackson shares examples where their models predicted optimal dosing schedules for anti-angiogenic therapies and identified synergistic interactions between cancer stem cell targeted therapies and traditional chemotherapy. These predictions were validated in preclinical studies, showcasing the impact of mathematical modeling in guiding effective treatment strategies.
Diversity Initiatives through Math Education Programs
The episode discusses Jackson's role in founding the Marjorie Brown Scholars Program, a course-based master's program aimed at preparing students for PhD studies in mathematics. This program, designed to enhance diversity in the field, offers funded opportunities for students to gain foundational math skills and explore research without traditional pressures. By nurturing a community of diverse scholars, such programs contribute to enhancing local and global diversity in mathematics.
Trachette L. Jackson earned her Ph.D. in Applied Mathematics from the University of Washington under the direction of Professor James D. Murray, one of the founding leaders in the field of Mathematical Biology. Ten years later, after postdoctoral positions at the IMA and Duke University, she was promoted to Full Professor of Mathematics at the University of Michigan. Dr. Jackson is an award-winning teacher-scholar whose research in mathematical oncology has received international attention. In 2003, she became the second African American woman to receive the prestigious Alfred P. Sloan Research Award in Mathematics. In 2005, Dr. Jackson received the James S. McDonnell 21st Century Scientist Award, and in 2008 Diverse Magazine honored her as one of the year’s Emerging Scholars. In 2010 she became the first woman to receive the Blackwell-Tapia Prize, which recognizes a mathematician who has contributed significantly to research and has served as a role model for mathematical scientists and students from underrepresented minority groups. More recently, Dr. Jackson was voted into the inaugural class of Association for Women in Mathematics (AWM) Fellows, the 2021 class of the Society of Industrial and Applied Mathematics (SIAM) Fellows, and the inaugural class of Simon’s Foundation Fellows, an honor featured in the NY Times. Dr. Jackson’s research lies within the overarching field of mathematical biology, which can be characterized by the use of sophisticated mathematical, statistical, and computational modeling techniques to facilitate a deep understanding of biology for human benefit and the mitigation of human harm. Within Mathematical Biology, she specializes in Computational Cancer Research or Mathematical Oncology. Mathematical and computational modeling approaches have been applied to every aspect of tumor growth from mutation acquisition and tumorigenesis to metastasis and treatment response. Dr. Jackson’s research focuses on developing mathematical methods to address critical questions associated with tumor progression and targeted therapeutics. Dr. Jackson has built her career on collaborative research and educational activities that cut across traditional disciplinary boundaries. She envisions that this type of research will eventually change the face of cancer research.
Lynn Brandon is Executive Editor for Mathematics, based in London, celebrating two decades with Springer in 2022. She manages a small team of editors and several journals, mostly in applied and computational mathematics.