TWiV 815: MIS-C with Moshe Arditi and Ivet Bahar

Moshe and Ivet join TWiV to discuss their finding that MIS-C is a consequence of a superantigen in the spike protein of SARS-CoV-2 that causes activation of a skewed population of T cell receptor bearing lymphocytes, leading to hyperinflammation.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit and Kathy Spindler

Guests: Moshe Arditi and Ivet Behar

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Links for this episode

• MIS-C in US children (NEJM)
• Superantigen in spike and T cell skewing in MIS-C (PNAS)
• MIS-C mimics toxic shock syndrome (J Allergy Clin Immunol)
• Antibody against bacterial superantigen blocks SARS-CoV-2 entry (Structure)
• Autoimmune signature of MIS-C in children (J Clin Invest)
• HLA1 associated T cell expansion in MIS-C (J Clin Invest)
• Passing of Bill Wold (one, two)
• Letters read on TWiV 815
• Timestamps by Jolene. Thanks!

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Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv