Pre PACES Podcast #44 Polycystic kidney disease
Oct 9, 2022
Dr. Revathi Whittaker-Jain, a Consultant Nephrologist known for her expertise in kidney diseases, returns to explore polycystic kidney disease. She explains the significance of PKD in examinations and its genetic basis. The discussion covers clinical presentations, imaging diagnostics, and common lead-ins for exams. Dr. Whittaker-Jain also highlights important complications, stresses the role of patient education, and details specific therapies like tolvaptan, ensuring listeners grasp the complexities of managing PKD.
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Why ADPKD Is A Common PACES Topic
- Autosomal dominant polycystic kidney disease (ADPKD) is the commonest inherited renal disease and often detectable at the bedside.
- Exam stations favour ADPKD because patients are young, often stable, and carry recognisable signs.
Cysts Compress Functional Kidney Tissue
- ADPKD causes progressive formation of non-functioning fluid-filled renal cysts that compress healthy parenchyma.
- This cyst growth explains progressive loss of renal function over time.
Key Genetics: PKD1 And PKD2
- ADPKD is genetically heterogeneous: PKD1 on chromosome 16 and PKD2 on chromosome 4 encode polycystin 1 and 2.
- PKD1 typically causes earlier, more severe disease than PKD2.