Ethris is developing mRNA-based candidates for the treatment of respiratory viral infections and rare pulmonary diseases, as well as prophylactic vaccines for mucosal, multivalent, and mutation-agnostic use.
Dr. Rudolph discusses the challenges in the mRNA field, including regulatory considerations, cold-chain storage requirements, and the need for creative reimbursement models.
Deep dives
The Potential of COVID Vaccines and mRNA Paradigm
The podcast episode discusses the potential of entering the COVID vaccine market from a new vaccine paradigm. It highlights the driving forces of COVID, fatigue, and vaccine hesitancy behind the commercial acceptance of a new product.
Dr. Karsten Rudoff's Background and Entry into mRNA Space
The episode explores Dr. Karsten Rudoff's background and how he entered the mRNA space. It discusses his research work in gene therapy for cystic fibrosis and the transition to using messenger RNA as a potential cure.
Advancements in Messenger RNA Technology
The podcast delves into the advancements in messenger RNA technology, specifically in the field of pulmonary therapeutics. It highlights the use of modified nucleotides and RNA structure modifications to reduce immune responses and enhance efficiency.
Challenges and Progress in the mRNA Field
The episode covers the challenges and progress in the mRNA field, including regulatory considerations, cold-chain storage requirements, and the need for creative reimbursement models. It also provides updates on ATHRYS' ongoing clinical trials and future plans for their primary ciliary dyskinesia (PCD) program.
Without doubt, the grand and collaborative experiment that was the mRNA COVID vaccine contributed mightily to the pandemic response and continues to save lives untold. It also demonstrated the collective power of public/private partnership in biopharma. Having acknowledged that, no first iteration of a new technology is ever the best iteration of that technology. On this week's episode of the Business of Biotech, we welcome Carsten Rudolph, Ph.D., co-founder and CEO of a company that recognizes this room for improvement. Ethris is developing mRNA-based candidates for the treatment of respiratory viral infections and rare pulmonary diseases, in addition to mucosal, multivalent, and mutation-agnostic prophylactic vaccines. Dr. Rudolph explains the concept, the business case, and how he's navigating Ethris toward a better treatment and vaccine paradigm in the wake of the pandemic.
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