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The podcast episode discusses advanced needle guidance using the Percunab system, which involves fusion software and navigation techniques. The fusion software allows for combining MRI or PET CT images with ultrasound images, increasing accuracy and confidence in procedures like biopsies and ablations. The navigation technique uses 3D ultrasound image fusion and navigation to access areas that are difficult to reach with conventional methods. The system requires a setup process involving patient trackers and the connection of cables and sensors. The learning curve for using the system is relatively short, with proficiency achieved after a few cases. The technology has the potential to revolutionize radiationless procedures, help in rural areas without CT scans, and reduce the need for rebiopsies.