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VJHemOnc Podcast
Comparing the ICC and WHO classifications for MDS and their impact on clinical practice
Mar 24, 2023
Experts Amer Zeidan and Sanam Loghavi discuss the updated ICC and WHO classifications for MDS. They explore the overlap and differences between the two systems and highlight the challenges in classifying MDS. The podcast also emphasizes the importance of a comprehensive report and the potential of AI in generating such reports. The significance of a uniform classification for MDS and its impact on clinical practice is highlighted, along with the need for improved treatments. Lastly, the podcast emphasizes the importance of providing accurate patient education resources and recognizing genetic abnormalities morphologically.
44:14
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Quick takeaways
- The WHO and ICC classifications for MDS differ in their inclusion of genetically and morphologically defined categories, highlighting the need for a unified system.
- The classification of MDS impacts clinical practice by influencing patient eligibility for clinical trials and reimbursement for treatments, emphasizing the importance of accurate diagnosis.
Deep dives
Evolution of Classification Systems for MDS
The podcast discusses the evolution of classification systems for myelodysplastic syndromes (MDS) from the French-American, British (FAB) system to the World Health Organization (WHO) and International Consensus Classification (ICC). The FAB system was based on blast percentages, while the WHO and ICC classifications incorporate genetic definitions. The 2016 WHO classification introduced genetic criteria and recognized distinct MDS categories based on gene mutations. The speaker emphasizes the importance of recognizing that patient care extends beyond the pathology report, as the classification impacts eligibility for clinical trials and reimbursement for treatments.
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Discover
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Listen to the best highlights from the podcasts you love and dive into the full episode