#13: AI, Work, and the Future of Life: Lessons on Success, Resilience, and Reinvention

Jun 4, 2025

52:16

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In this inspiring conversation, we explore how AI will transform the future of business and work, and what it means for us as humans. You’ll hear why AI will soon perform 80% of 80% of human jobs, why full AI-first tools will surpass today’s co-pilots, and why most of AI’s impact will happen outside of tech.

But this is also a powerful life masterclass. From building billion-dollar startups to raising a family and staying energized at 70, we dive deep into resilience, happiness, and living an internally driven life.

You’ll learn how to power through failure, lead through change, balance ambition with presence, and why the most significant measure of life is doing what you love.

Follow Vinod Khosla – X (Twitter): https://twitter.com/vkhosla

Follow Derek – X (Twitter): https://twitter.com/derekjandersena

Timestamps:

00:00 - Introduction to AI and Entrepreneurial Vision

05:01 - The Future of AI Development and Adoption

10:01 - AI's Impact on Business and Job Transformation

15:02 - AI as a Tool for Small Businesses and Innovation

20:00 - The Role of Startups and Disruption in AI

25:00 - Preparing for an AI-Driven Future

30:02 - Lessons from Building Tech Companies

35:01 - Staying Relevant and Evolving as an Investor

40:00 - Balancing Work, Family, and Personal Growth