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ImmunoTea: Your Immunology Podcast
ImmunoTea Episode 8 - Cytokine Biology and Translational Immunology
Aug 21, 2023
Dr. Darragh Duffy, a translational immunology expert involved in the Milieu Interieur project, dives into the complexities of immune responses. He discusses the critical role of type 1 interferons in viral infections and their influence on autoimmune conditions, along with recent insights from COVID-19 research. The conversation also covers JAK inhibitors and their benefits for autoimmune diseases, the nuanced use of steroids in treatment, and groundbreaking research on immune diversity, all while keeping things engaging and light-hearted!
32:30
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Quick takeaways
- Type 1 interferons are critical for antiviral responses and are linked to autoimmune conditions, affecting the severity of diseases like COVID-19.
- The Milieu Interieur project explores how genetics and lifestyle influence immune responses, aiming to improve diagnostics and treatments in immunology.
Deep dives
Understanding Type 1 Interferons
Type 1 interferons play a crucial role in the immune system, particularly in responding to viral infections. These cytokines were the first to be identified and are essential for the antiviral immune response, but they are also linked to various autoimmune conditions. Research indicates that individual differences in type 1 interferon responses can significantly influence the severity of diseases like COVID-19. Low levels of type 1 interferon in critical patients have been associated with worse clinical outcomes, emphasizing its importance in immune function.
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