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VJHemOnc Podcast

Post-ASH MDS highlights: managing anemia in LR-MDS and novel approaches to treating HR-MDS

Jan 17, 2025
This discussion dives into groundbreaking findings from the ASH annual meeting, focusing on managing anemia in lower-risk myelodysplastic syndromes. Experts share compelling results from the EPO-Pretar trial, emphasizing the timing of epoetin alfa treatment. The superiority of Luspotercept over traditional treatments for anemia is also highlighted. Additionally, innovative strategies for high-risk MDS are explored, including personalized stem cell transplantation and novel therapies targeting P53 mutations, showcasing the evolving landscape of treatment options.
19:03

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Quick takeaways

  • Early administration of erythropoiesis-stimulating agents significantly reduces transfusion dependence in lower-risk MDS patients, as shown in recent trials.
  • Innovative approaches for higher-risk MDS, such as sequential allogeneic stem cell transplantation, are emerging despite associated toxicity challenges and early mortality rates.

Deep dives

Trial Updates on Anemia Management in Lower-Risk MDS

Recent trials have provided important insights into managing anemia in patients with lower-risk myelodysplastic syndromes (MDS). The phase 3 EPO-Protar trial highlighted how the timing of erythropoiesis-stimulating agent (ESA) administration impacted transfusion dependence. Specifically, patients receiving ESA early, within six months of diagnosis, demonstrated a longer time to transfusion dependence compared to those treated later. Furthermore, the early ESA group had a higher erythroid response rate of 79%, suggesting that early intervention is more effective, although this did not translate to improved quality of life scores.

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