Cardiac Clarity: Dr. Keith Channon Talks Revolutionizing Heart Health With AI - Ep. 212
Jan 31, 2024
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Dr. Keith Channon, a cardiologist, discusses Caristo Diagnostics' AI technology for detecting coronary inflammation. The podcast highlights the limitations of current diagnostic methods and the need for improved inflammation detection. The role of inflammation in heart disease is explored, along with how AI can analyze CT scan data and correlate it with inflammation. AI and radiomics are discussed for disease biomarker discovery, and the potential impact on interpreting cardiac CT scans is emphasized. The importance of heart health and the potential of AI in healthcare are also addressed.
Caristo Diagnostics has developed an AI-powered solution called Carry Heart that can detect coronary inflammation from routine cardiac CT scans, providing clinicians with person-specific inflammation levels and absolute risk scores for heart attack.
Identification of inflammation accurately and early is crucial for developing appropriate treatment plans and reducing the global burden of heart attack-related deaths.
Deep dives
Spotting Coronary Inflammation in CT Scans
Carista Diagnostics has developed an AI-powered solution that can detect coronary inflammation and predict heart attacks years in advance. The technology, called Carista's Carry Heart, analyzes routine cardiac CT scans to identify inflammation in the fat tissue surrounding the coronary arteries. Research studies have shown that patients with high inflammation, even without significant arterial narrowing, have a tenfold increased risk of heart attack or death in the next decade. The Carry Heart report provides clinicians with a person-specific inflammation level and an absolute risk score for heart attack. Carista is working with five NHS hospitals in the UK to assess the impact of Carry Heart on CT scan interpretation and patient management.
Understanding the Clinical Problem
Despite advancements in cardiac CT scans, the current focus is on detecting arterial narrowing or blockages rather than inflammation. Inflammation is the driver of coronary artery disease, and traditional blood tests fail to provide precise identification of patients with inflammation. The consequences are that patients with minimal or no plaque formation, but high inflammation, are at increased risk of heart attacks. Identifying inflammation accurately and early is crucial for developing appropriate treatment plans and reducing the global burden of heart attack-related deaths.
The Breakthrough: Radiotranscriptomic Analysis
The breakthrough in Carista's research involved the analysis of molecular signals in the fat tissue surrounding the coronary arteries to detect inflammation. By using tissue biopsies and molecular techniques, the researchers found strong correlations between inflammation-related gene expression and changes in imaging characteristics of the fat tissue using AI-driven radiomics. This led to the discovery of a new biomarker known as the fat attenuation index (FAI), which quantifies inflammation in the coronary arteries and predicts individuals' risk of heart attack.
Future Plans and Impact
Carista aims to expand the clinical use of the Carry Heart technology through regulatory approvals, including FDA approval in 2024. The software platform allows physicians to upload CT scans from any manufacturer's CT scanner, enabling analysis of inflammation and plaque. Pilot studies have shown that Carry Heart significantly modifies patient treatment plans, with 45% of patients receiving different recommendations compared to standard clinical care. Carista also plans to collaborate on identifying patients with high inflammation levels for targeted anti-inflammatory treatments and contribute to advancements in pharmaceutical approaches.
Here’s some news to still beating hearts: AI is helping bring some clarity to cardiology. Caristo Diagnostics has developed an AI-powered solution for detecting coronary inflammation in cardiac CT scans. In this episode of NVIDIA’s AI Podcast, Dr. Keith Channon, cofounder and chief medical officer at the startup, speaks with host Noah Kravtiz about the technology. Called Caristo, it analyzes radiometric features in CT scan data to identify inflammation in the fat tissue surrounding coronary arteries, a key indicator of heart disease. Tune in to learn more about how Caristo uses AI to improve treatment plans and risk predictions by providing physicians with a patient-specific readout of inflammation levels.
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