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Target The Right Patients And Duration In Oxygen Trials
- Design oxygen trials to target relevant, vulnerable populations and longer exposure periods to detect biologically plausible harms.
- Consider powering studies for specific subgroups (severe head/chest injury) rather than broad trauma cohorts.
Keep Oxygen Targets Practical And Safe
- Aim for safe oxygenation and avoid hypoxia, particularly in head-injured or very sick trauma patients.
- Do not change routine practice solely based on TRAUMOX2; check and titrate oxygen to sensible targets (≈94%).
Composite Endpoints Can Cancel Opposing Effects
- Composite endpoints can mask opposing effects by cancelling components like mortality and respiratory complications.
- That cancellation may hide clinically important benefits or harms of an intervention.