CMAJ Podcasts More than just novel obesity treatments
Jan 29, 2024
This podcast explores the impact of new medications like semaglutide and tirzepatide in treating obesity, including their effects on weight loss and cardiometabolic health. The conversation emphasizes the need for a comprehensive approach to obesity management, considering realistic expectations, self-image concerns, and long-term metabolic health. It also discusses societal biases and stigmas around obesity, highlighting the necessity for a change in how physicians and society view this medical condition. The podcast covers the potential impact of novel obesity treatments on surgical management, the effects of medications on patients with obesity and diabetes, criteria for enrolling patients in obesity medication trials, contraindications and complications, and dosing and titration of obesity medications.
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Managing Side Effects
- Start GLP-1 agonists at a low dose and titrate slowly.
- This helps manage gastrointestinal side effects like nausea and discomfort.
Hormonal Impact of GLP-1s
- GLP-1 medications are hormones that affect other hormones.
- Significant weight loss can lead to bone density and muscle mass changes.
Biggest Loser Study
- Biggest Loser contestants experienced decreased resting metabolic rates after extreme weight loss.
- This metabolic slowdown made it harder to maintain the weight loss.