Wits & Weights | Fat Loss, Nutrition, & Strength Training for Lifters Can THIS Plant Extract Activate GLP-1 Like Ozempic? (Sarah Kennedy) | Ep 427
Jan 16, 2026
In an enlightening discussion, Sarah Kennedy, a veterinarian and founder of CaloCurb, delves into the biology of hunger and appetite regulation. She explains how gut hormones, particularly GLP-1, influence cravings and weight loss. Sarah highlights the role of bitter compounds found in hops and their potential to suppress appetite naturally. She also uncovers significant differences in appetite response in women and reveals the promising effects of her product in comparison to traditional weight loss medications. This episode reframes hunger as a physiological issue, emphasizing practical solutions for managing cravings.
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Hunger Is A Primitive Biological Signal
- Hunger is driven by primitive hindbrain signals like ghrelin that evolved to make us seek food when calories fall.
- A 25% calorie cut can double subjective hunger in four months, explaining why most diets fail.
Bitter Receptors Live Throughout The Gut
- Researchers mapped bitter taste receptors along the human gut and found they trigger hormone release when stimulated.
- Screening >1,000 extracts identified a specific hops extract (amarasate) as a potent stimulator.
Targeted Delivery Produces Large Hormone Spikes
- Delivering the hops extract to the upper duodenum massively amplifies GLP‑1 and other satiety hormones.
- The extract produced a ~18% average drop in calories eaten versus placebo in a human trial.