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Optimize Before Biologics
- Assess inhaler technique and comorbidities before starting biologics for asthma.
- Ensure correct inhaler use to differentiate difficult-to-treat from severe asthma.
Biologic Targets in Type 2 Asthma
- Biologic therapies target specific immune pathways in type 2 inflammation.
- Key targets include IgE, IL-5, IL-4, IL-13, and TSLP molecules.
Biologic Initiation Criteria
- Consider biologics for patients uncontrolled on high-dose ICS-LABA with frequent exacerbations.
- Confirm type 2 inflammation evidence like elevated eosinophils or FeNO before initiating biologics.