

5. Hypertrophic Cardiomyopathy Historical Perspective with Dr. Edward Kasper
Jan 5, 2020
Dr. Edward Kasper, director of clinical cardiology at Johns Hopkins Medicine, offers a fascinating historical perspective on hypertrophic cardiomyopathy (HCM). He highlights the evolution of medical understanding of HCM since 1958, emphasizing the role of genetic research and collaboration among healthcare providers. Dr. Kasper also discusses the benefits of rinolazine for managing angina, and the importance of personalized patient care. His passion for fostering long-term patient relationships showcases the rewarding nature of practicing medicine.
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Index Case
- Dr. Kasper's interest in HCM began with a transplant patient diagnosed with IHSS by Dr. Braunwald.
- This patient's case sparked his fascination with the historical debates surrounding HCM.
Rapid Evolution of HCM
- HCM's understanding has rapidly evolved within Dr. Kasper's lifetime, from initial descriptions to genetic discoveries.
- Key milestones include the first myectomy (1960), echocardiography (1969-70), and gene identification (1990).
Braunwald's Early Cases
- Dr. Braunwald's initial HCM cases, referred for surgery, revealed no obstruction under cardiopulmonary bypass.
- This experience highlights his brilliance in recognizing a new disorder despite initial setbacks.