The First Woman To Get A New Kind Of Kidney Transplant
Dec 20, 2024
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Rob Stein, NPR's health correspondent, shares the groundbreaking story of Tawana Looney, the first person to receive a genetically modified pig kidney. Tawana, a resilient grandmother from Alabama, had been on dialysis for years before this pioneering transplant. Stein was present in the operating room, providing an exclusive look at the procedure. They discuss the ethical controversies surrounding animal organ transplants and the potential for this innovation to address the severe shortage of human donors. Tawana's inspiring recovery highlights hope in this medical frontier.
Towana Looney's successful kidney transplant from a genetically modified pig marks a significant advancement in addressing organ shortages and patient needs.
The procedure sparks debate over ethical implications and safety concerns regarding genetically modified organs amidst the ongoing organ transplant crisis.
Deep dives
Advancements in Transplantology Using Genetically Modified Pig Organs
A biotech company, Revivacor, is working on using cloned, genetically modified pigs to provide organs for human transplants, aiming to solve the pressing organ shortage crisis. These pigs have ten identical genetic modifications designed to create organs that are compatible with human patients, reducing the risk of rejection and complications like blood clots. During a recent surgery, the first pig kidney from this project was transplanted into a patient, showcasing a novel approach that could change the landscape of transplant medicine. The operation is especially noteworthy as it addresses the urgent need, given that more than 100,000 people in the U.S. are on transplant waiting lists, with many dying without receiving a suitable organ.
Patient Experience and the Innovative Surgery
Tawana Looney, the first patient to receive a genetically modified pig kidney, has undergone a significant medical transformation after years of being on dialysis. Having developed chronic kidney failure after donating a kidney to her mother, her desperate situation allowed her to participate in this experimental surgery under a compassionate use framework, which provides access to potentially life-saving treatments. The operation was dramatic, with the pig kidneys arriving mid-surgery, and after the successful transplant, Tawana experienced a rejuvenating recovery, regaining the ability to perform daily activities that had been challenging for years. Her optimism shines through as she looks forward to reuniting with her family and returning to her job, highlighting the personal impact of this groundbreaking medical approach.
Ethical Concerns Surrounding Animal-to-Human Organ Transplants
The controversial nature of using genetically modified pig organs raises significant ethical and safety concerns among experts in the field. Bioethicists express worries about the potential for transmitting animal viruses to humans, which could alarmingly lead to new pandemics and exploit vulnerable patients seeking desperate solutions. There's skepticism regarding the adequacy of scientific evidence supporting such procedures, particularly given the risks involved for patients without proper clinical trial oversight. Despite these concerns, the dire situation for patients like Tawana prompts a complex discussion about the balance between hope for innovative solutions and the need for rigorous scientific validation.
Towana Looney became the first living person in the world to get a kidney from a new kind of genetically modified pig last month. Health correspondent Rob Stein got exclusive access to be in the operating room.
Towana is a 53-year-old grandmother from Gadsden, Ala. She's been on dialysis for four hours a day, three days a week since 2016. Her immune system would reject a human kidney. So the Food and Drug Administration made an exception to its usual clinical study requirements to allow Looney this new kind of pig kidney. But the procedure is controversial.
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