Recurrent pregnancy loss is devastating for the affected couple. In part 1, we will review the diagnosis of this condition. We will also cover parental genetics, APS, and uterine anomalies. In part 2, we will see if thrombophilia testing is indicated, discuss progesterone supplementation, and what role/if any, immunological reactions have with recurrent miscarriage. (Data from ASRM, ACOG, and RCOG).