Freely Filtered 037: The first Guideline Draft: KDIGO Hypertension Guidelines

The Filtrate:

Joel Topf

Swapnil Hiremath

Nayan Arora

Sophie Ambruso

Joshua Weisman

Editor

Joel Topf

Show Notes:

Soccer star Christian Eriksen 'was gone' after on-field cardiac arrest, doctor says (NBC News)

120-sided Die. This was covered in Wired Magazine. Respect. https://www.wired.com/2016/05/mathematical-challenge-of-designing-the-worlds-most-complex-120-sided-dice/

Nephrologists that played D&D: https://twitter.com/kidney_boy/status/1398660927680036865?s=20

Doctors that played D&D (i.e. control group): https://twitter.com/kidney_boy/status/1398661170328899586?s=20

Average sodium intake among Americans is 3,400 mg (147 mEq of Na per day). Sodium and the Dietary Guideline Factsheet (PDF)

DASH Sodium Diet Trial https://www.nejm.org/doi/10.1056/NEJM200101043440101

The PURE Trial as discussed by NephJC and as seen in the NEJM

Formulas to Estimate Dietary Sodium Intake From Spot Urine Alter Sodium-Mortality Relationship https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.13117

The Taiwan Nursing Home study: https://pubmed.ncbi.nlm.nih.gov/16762939/

Peruvian Cluster RCT of sodium reduction in Nature (oooh!) https://www.nature.com/articles/s41591-020-0754-2

DASH Diet in CKD https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957723/

A comparison of treating metabolic acidosis in CKD stage 4 hypertensive kidney disease with fruits and vegetables or sodium bicarbonate https://pubmed.ncbi.nlm.nih.gov/23393104/

ACCORD https://www.nejm.org/doi/full/10.1056/nejmoa1001286

Kidney Damage Biomarkers and Incident CKD During Blood Pressure Reduction: A Case-Control Study within SPRINT https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953744/

Association of Urinary Biomarkers of Inflammation, Injury, and Fibrosis with Renal Function Decline: The ACCORD Trial https://pubmed.ncbi.nlm.nih.gov/27189318/

Lake Wobegon https://en.wikipedia.org/wiki/Lake_Wobegon

SPRINT https://www.nejm.org/doi/full/10.1056/nejmoa1511939

Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia https://jamanetwork.com/journals/jama/fullarticle/2723256

Characterizing Frailty Status in the Systolic Blood Pressure Intervention Trial https://pubmed.ncbi.nlm.nih.gov/26755682/

Syncope, Hypotension, and Falls in the Treatment of Hypertension: Results from the SPRINT Randomized Clinical Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045467/

The USPSTF recommends screening for hypertension in adults 18 years or older with office blood pressure measurement (OBPM). The USPSTF recommends obtaining blood pressure measurements outside of the clinical setting for diagnostic confirmation before starting treatment. https://www.uspreventiveservicestaskforce.org/uspstf/recommendation/hypertension-in-adults-screening

Concordance Between Blood Pressure in the Systolic Blood Pressure Intervention Trial and in Routine Clinical Practice https://pubmed.ncbi.nlm.nih.gov/33044494/