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Early intervention for patients with smoldering myeloma is gaining attention due to potential survival benefits. Recent findings from the Aquila study indicated that treating high-risk smoldering myeloma patients with daratumumab monotherapy resulted in improved overall survival when compared to observation. Data from the I-STOP trial revealed that a significant number of people may live with smoldering myeloma, prompting the need for careful consideration of intervention strategies. However, it remains essential to ensure patients do not have active myeloma before initiating daratumumab treatment, necessitating thorough imaging assessments.