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VJHemOnc Podcast

Post-ASH myeloma highlights: key takeaways for community physicians & trials to look out for in 2025

Feb 6, 2025
Discover groundbreaking insights on treating smoldering myeloma, with a focus on the AQUILA study showcasing daratumumab's survival benefits. Delve into the advancements in bispecific antibodies, revealing new treatment options for relapsed myeloma. The experts forecast exciting developments for 2025, emphasizing the role of measurable residual disease (MRD) in patient outcomes. Additionally, explore the evolving definition of high-risk myeloma and the emergence of innovative therapies for these challenging cases.
18:29

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Quick takeaways

  • Early intervention in high-risk smoldering myeloma via daratumumab monotherapy shows improved survival benefits compared to observation.
  • The rise of bispecific antibodies offers promising initial responses for relapsed refractory multiple myeloma, necessitating vigilant infection monitoring.

Deep dives

Early Intervention in Smoldering Myeloma

Early intervention for patients with smoldering myeloma is gaining attention due to potential survival benefits. Recent findings from the Aquila study indicated that treating high-risk smoldering myeloma patients with daratumumab monotherapy resulted in improved overall survival when compared to observation. Data from the I-STOP trial revealed that a significant number of people may live with smoldering myeloma, prompting the need for careful consideration of intervention strategies. However, it remains essential to ensure patients do not have active myeloma before initiating daratumumab treatment, necessitating thorough imaging assessments.

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