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ACCEL Lite: Featured ACCEL Interviews on Exciting CV Research
Effect of Antihypertensive Timing on Mortality and Morbidity: BedMed and BedMed-Frail Trials
Oct 22, 2024
Recent trials have clarified that the timing of antihypertensive medication—whether morning or evening—has no significant impact on major cardiovascular events. Drs. DeMaria and Garrison discuss the unique challenges faced by general and frail populations in clinical trials. They emphasize the importance of medication adherence over timing and how individual patient preferences should shape dosing schedules. Additionally, the role of circadian rhythms in blood pressure management is explored, indicating that personalizing treatment may yield better outcomes.
12:09
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Quick takeaways
- The BedMed and BedMed-Frail trials concluded that the timing of antihypertensive medication intake has no significant impact on cardiovascular outcomes.
- Emphasizing patient adherence to medication schedules over specific timing can enhance overall treatment effectiveness and ease patient burden.
Deep dives
Timing of Antihypertensive Medications
Recent studies have investigated the timing of antihypertensive medication intake, with a focus on whether taking these medications at bedtime offers any cardiovascular benefits compared to morning intake. Previously published research from a Spanish trial showed potential advantages with nighttime dosages, suggesting a significant reduction in major adverse cardiovascular events (MACE). However, more recent data from multiple trials, including BedMed and BedMed Frail, demonstrated no significant difference in outcomes regardless of medication timing. Notably, the hazard ratios from these trials were very close to one another, indicating that both morning and bedtime intake do not alter cardiovascular event rates.
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