DNA Today: A Genetics Podcast

#374 The Eras of Genetic Testing: From the Human Genome Project to Precision Medicine

Jan 2, 2026
Rome Madison, a precision medicine and diagnostics industry leader, shares his journey in the field after the Human Genome Project. He reveals the evolution of genetic testing, from early pharmacogenomics to today’s precision medicine. Rome discusses the barriers of adoption, including costs and skepticism, and emphasizes the importance of patient access. Personal connections within his family inspire his commitment to improving outcomes. He also predicts a future with AI, multi-omics, and a shift towards preventive care empowered by patient data.
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ANECDOTE

Self-Taught Rep Who Saved His Father

  • Rome Madison taught himself oncology from books while unemployed and landed a role marketing an assay that predicted chemotherapy response.
  • He later watched his father undergo surgery and credited that work with helping secure a favorable molecular profile and long-term survival.
INSIGHT

Creating Demand, Not Just Offering Tests

  • Early precision medicine required persuading skeptical clinicians and creating demand from scratch.
  • Rome says adoption was sparse and reps had to be memorable to get clinicians to try genomic testing.
INSIGHT

Biomarkers Turned Fatal Diseases Treatable

  • Targeted biomarkers and drugs transformed diseases like metastatic melanoma from rapidly fatal to treatable or curable.
  • Rome highlights BRAF inhibitors and immunotherapies as turning points for long-term survivorship.
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