The Intern At Work: Internal Medicine cover image

The Intern At Work: Internal Medicine

214. Small But Mighty - An Internist's Approach to Small Cell Lung Cancer

Nov 12, 2023
This podcast episode discusses the clinical presentation, classification, investigations, treatment, and prognosis of small cell lung cancer. It explores the aggressive nature, poor prognosis, and causes of SCLC, as well as the various treatment options including chemotherapy and radiotherapy. The controversial topic of prophylactic cranial radiation is also explored, along with the importance of routine MRI imaging and involvement of other specialists in patient care.
13:13

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Quick takeaways

  • Small cell lung cancer is an aggressive subtype characterized by high cell proliferation and metastatic potential.
  • Patients with small cell lung cancer commonly present with symptoms related to invasion, metastases, and paraneoplastic syndromes.

Deep dives

Understanding Small Cell Lung Cancer

Small cell lung cancer is an aggressive subtype of lung cancer with a poor prognosis. It is characterized by high cell proliferation and metastatic potential. Standard treatments have not significantly changed in decades, prompting intense research into the cellular mechanisms driving progression and resistance. Small cell lung cancer is classified based on neuroendocrine tumor features and is often diagnosed at an advanced stage, leading to low survival rates. The primary cause of small cell lung cancer is smoking, though other mutations may also contribute.

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