

Why are measles cases surging?
Apr 8, 2025
In this insightful discussion, Paul Dupre, Director of the Centre for Vaccine Research and a Professor of Microbiology and Molecular Genetics at the University of Pittsburgh, dives into the alarming global resurgence of measles. He explores the virus's origins and its devastating effects on human immunity. Dupre emphasizes the urgent need for renewed vaccination efforts, especially in communities with declining rates. He also tackles the impact of misinformation on vaccine hesitancy, advocating for effective communication strategies to restore public trust in health initiatives.
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Origins and Infectivity of Measles
- Measles originated from a cattle virus called Rinderpest, crossing to humans about 2000 years ago.
- It is extremely infectious and causes lifelong immunity after infection or vaccination, making it potentially eradicable.
Measles Immune Impact
- Measles spreads via respiratory droplets before symptoms appear and infects many organs.
- It destroys immune memory cells, causing immune amnesia and increased vulnerability to other infections.
Herd Immunity Threshold Importance
- Measles vaccine effectiveness depends on achieving over 95% population coverage for herd immunity.
- Coverage below this threshold allows measles to spread rapidly and causes outbreaks in unvaccinated groups.