The Evolving World of RNA Editing with Dr. David Nelles

As the year comes to an end, we would like to thank everyone who listened to the FYI — For Your Innovation podcast. 2021 was another up and down year, as the world continues to battle the COVID-19 pandemic. In this final episode of 2021, we compiled some of our most interesting podcast episodes for you. Please enjoy this summary and tune back in when we return in 2022 with a new and improved version of FYI.

• Factors that caused CRISPR to dominate the gene editing space.
• David explains the difference between DNA and RNA, using a football analogy.
• The goal that David centered his PhD around.
• Variety that exists amongst RND molecules.
• Benefits of targeting RNA in diseased cells, rather than DNA.
• Why RNA lagged behind DNA in terms of technological developments.
• A theory about the role played by RNA in the past.
• Methods of RNA editing.
• Comparing homology directed repair (HDR) and non homologous end joining (NHEJ).
• David provides a breakdown of the various different guides and enzymes.
• Three kinds of vector systems, and how they work.
• Examples of the types of RNAs that exist.
• What David is excited about in the future of the RNA technology field.