The Nephron Segment: A Kidney Podcast

Episode 12: A SPRINT Through HTN Trials

Dec 29, 2023

Dr. William Cushman discusses SPRINT Trial & hypertension trials history, blood pressure guidelines evolution, cognitive benefits, & adverse events, highlighting trial outcomes & future insights in managing hypertension.

00:00

Creator website

Episode guests

William Cushman

AI Summary

AI Chapters

Episode notes

Podcast summary created with Snipd AI

Quick takeaways

SPRINT Trial showed a 25% reduction in cardiovascular events with intensive blood pressure control.

Intensive blood pressure control in SPRINT Trial led to unexpected cognitive benefits, challenging existing guidelines.

Deep dives

Overview of the SPRINT Trial

The SPRINT Trial, published in 2015, involved over 9,000 high-risk participants aged 50 and above. The study randomized participants to intensive systolic blood pressure goal of less than 120 mm Hg versus a standard goal of 140 mm Hg. After about three years, the data revealed a significant 25% benefit in reducing fatal and non-fatal cardiovascular events, and a 25-30% decrease in all-cause mortality compared to the standard group.

Intro

2min

Unforeseen Entry into Hypertension Research and Trials

2min

The Impact of the SPRINT Trial on Hypertension Guidelines

15min

Insights from the SPRINT Study on Hypertension

10min

Surprising Findings and Adverse Events in a Hypertension Trial

3min

Inclusion and Exclusion in Hypertension Trials

4min

In Episode 12, Dr. William Cushman, co-investigator of the 2015 SPRINT (Systolic Blood Pressure Intervention) Trial, joins us for a discussion all about hypertension trials, their long history, and what's ahead for research in this space. Too young to remember SPRINT or looking for a "CliffsNotes" of HTN trials? This episode's for you!

Here's a Renal Fellow Network post from 2017 with a link to a cheat sheet of hypertension clinical trial.

Nephrons: Matthew Sparks, Samira Farouk

Guests: William Cushman, Medical Director & Professor, Department of Preventive Medicine, University of Tennessee

Links from the Show:

00:41: Systolic Blood Pressure Intervention Trial (2015)

02:17: VA Cooperative Study (1967)

05:13: ACCORD Study (2010)

06:30: SPRINT MIND (2019)

08:40: Framingham Heart Study (Started 1948)

11:27: Attended vs. unattended blood pressure – learnings beyond SPRINT (2021)

14:03: Systolic Hypertension in the Elderly Program Study (1989)

14:05: Hypertension Detection & Follow Up Program (1979)