Extracorporeal Liver Support with Dr. Ayse Akcan Arikan -- Part 2

Jun 17, 2024

Dr. Ayse Akcan Arikan discusses the implementation of extracorporeal liver support, management of hepatic encephalopathy, ethical dilemmas in therapy decisions, positive outcomes for teenagers with liver failure, and challenges in providing high-resource therapies to pediatric patients with acute liver failure.

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Intro

00:00 • 2min

Management of Hepatic Encephalopathy with CRRT, TPE, and MARS

02:05 • 6min

Ethical Dilemma in Offering Advanced Blood Purification Therapies to Non-Liver Transplant Candidates

08:20 • 4min

Emphasizing Positive Outcomes for Teenagers with Liver Failure

12:44 • 1min

Challenges in Providing High-Resource Therapies to Pediatric Patients with Acute Liver Failure

13:54 • 16min

Ayse Akcan Arikan, MD is a dual trained pediatric intensivist and nephrologist and an Associate Professor of Pediatrics with tenure at Baylor College of Medicine. She is the Associate Chief (Research) of the Division of Critical Care Medicine. Dr Arikan is a clinician-scientist whose research focus is on the recognition and management of acute kidney injury in the critically ill, pharmacokinetics in extracorporeal therapies, management of multiple organ failure, as well as sepsis resuscitation and outcomes. Dr Arikan also serves as the Medical Director of the Critical Care Nephrology and Inpatient Dialysis and the Medical Director of the Extracorporeal Liver Support programs at Texas Children’s Hospital. She is an international leader in pediatric extracorporeal renal and liver support.

Learning Objectives:

By the end of this podcast, listeners should be able to discuss:

The rationale for using extracorporeal liver support in patients with acute liver failure.
The various modalities of extracorporeal liver support and their advantages and disadvantages.
An expert’s approach to utilization of extracorporeal liver support in patients with acute liver failure.

References:

Akcan Arikan, Ayse MD1,2; Srivaths, Poyyapakkam MD1; Himes, Ryan W. MD3; Tufan Pekkucuksen, Naile MD1; Lam, Fong MD2; Nguyen, Trung MD2; Miloh, Tamir MD3; Braun, Michael MD1; Goss, John MD4; Desai, Moreshwar S. MD2. Hybrid Extracorporeal Therapies as a Bridge to Pediatric Liver Transplantation*. Pediatric Critical Care Medicine 19(7):p e342-e349, July 2018. | DOI: 10.1097/PCC.0000000000001546

Mitzner SR. Extracorporeal liver support-albumin dialysis with the Molecular Adsorbent Recirculating System (MARS). Ann Hepatol. 2011 May;10 Suppl 1:S21-8. PMID: 21566251.

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