Neurology Minute
An Angiotensin Receptor Blocker for Hypertension Is Associated With a Reduced Risk for Epilepsy
Jul 16, 2024
Dr. Halley Alexander discusses a study showing a lower risk of epilepsy in hypertensive patients using angiotensin receptor blockers (ARBs) like losartan. The analysis of a large patient database revealed a significant decrease in epilepsy incidence among those prescribed ARBs.
03:23
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Quick takeaways
- Patients taking angiotensin receptor blockers have a reduced risk of epilepsy compared to other antihypertensive agents.
- Losartan, an ARB, may lower epilepsy incidence by suppressing cascades and protecting the blood-brain barrier.
Deep dives
Study Replication: ARBs and Reduced Risk of Epilepsy
In a large retrospective cohort study, researchers replicated findings that patients with hypertension taking angiotensin receptor blockers (ARBs) had a reduced risk of developing epilepsy compared to other antihypertensive agents. The study, including over 2 million patients, matched ARB users with patients on ACE inhibitors, beta blockers, and calcium channel blockers using propensity score matching. Results indicated a decreased incidence of epilepsy with ARB usage compared to ACE inhibitors, beta blockers, and a combination of other antihypertensive classes, suggesting a potential association between ARBs and lower epilepsy development.
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