EFR 919: The Gut–Brain–Immune Connection: The New Science of Inflammation and Why You Can't Heal the Gut Without Healing the Mind with Will Bulsiewicz

This episode is brought to you by Joi & Blokes, Fatty15, and Strong Coffee Company.

In this powerful conversation, Dr. Will Bulsiewicz, MD joins Ever Forward Radio to explore why true healing goes far beyond food, supplements, and exercise—and into the nervous system, emotional health, and human connection. Drawing from his new book Plant Powered Plus, Will explains how inflammation is driven by an inseparable triad of gut microbiome imbalance, immune dysfunction, and a compromised gut barrier, while also revealing how chronic stress, unresolved trauma, loneliness, and circadian disruption can prevent the body from ever feeling safe enough to heal. This episode clearly explains the gut–brain–immune axis, the role of parasympathetic "safety" states, why PTSD and trauma leave measurable signatures in the gut, and how practices like sunlight exposure, breathwork, meaningful relationships, and spiritual purpose are not "woo"—but biology.

Follow Will @theguthealthmd

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00:00 – Introduction: Why You're Not Healing (It's Not Just Food)

01:30 – Inflammation, Strength & the Core Thesis of Plant Powered Plus

02:25 – 70% of the Immune System Lives in the Gut

03:40 – The Inflammation Trifecta: Dysbiosis, Gut Barrier & Immunity

05:10 – How Fast the Gut Microbiome and Gut Lining Can Heal

06:00 – 450,000 New Gut Cells Every Second

09:00 – Why the Body Wants to Heal (If We Let It)

10:00 – Morning Sunlight, Circadian Rhythm & Energy

11:30 – Gut Microbes Follow a 24-Hour Schedule

12:45 – Why the Immune System Is Active at Night

14:00 – Serotonin, Melatonin & Gut Repair

16:00 – Cortisol: When Stress Helps vs. Harms

18:30 – The Sympathetic Nervous System & "Berserker Mode

21:45 – How Chronic Stress Damages the Gut Barrier

24:00 – Trauma, PTSD & Inflammatory Disease

26:00 – Why You Can't Out-Diet Trauma

29:00 – Science, Pattern Recognition & the Mind–Body Connection

32:00 – Parasympathetic Healing: Safety, Rest & Digestion

34:00 – Breathwork, Meditation & Nervous System Regulation

36:00 – Human Connection as Medicine

38:30 – Loneliness, Mortality & Modern Society

43:00 – Why Meaningful Relationships Are Essential for Health

46:00 – Can You Be Healthy Without Deep Connection?

49:00 – Measuring Stress: HRV, Wearables & Inflammation

55:30 – Trauma, PTSD & the Gut Microbiome

58:00 – Healing Trauma and Healing the Gut Together

1:03:30 – Dr. Bulsiewicz's Personal Healing Story

1:09:30 – Reconciliation, Grief & Spiritual Healing

1:18:00 – Purpose, Faith & the Limits of Science

1:22:00 – Ever Forward

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Episode resources:

• Get 50% off any diagnostic labs with code CHASE at https://www.JoiAndBlokes.com/chase
• Get an additional 15% off the 90-day starter kit of C15:0 essential fatty acids https://www.Fatty15.com/everforward
• Save 15% on organic coffee and lattes with code CHASE at https://www.StrongCoffeeCompany.com
• Watch and subscribe on YouTube
• Get Will's new book, Plant Powered PLUS
• Learn more at TheGutHealthMD.com