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Master Brewers Podcast

Episode 130: Yeast Genome Changes During Serial Repitching

Oct 30, 2023
Maitreya Dunham and Tom Schmidlin discuss an exciting study on yeast mutations during serial repitching. They explore the implications of serial re-pitching in yeast, understanding mutants in yeast genome changes, studying the evolution of Chico yeast strains, and methods of tracking mutations in yeast genomes.
40:16

Podcast summary created with Snipd AI

Quick takeaways

  • Yeast cells undergo various genome changes during cereal re-pitching, impacting metabolite production, growth, and stress tolerance.
  • Brewing strains have unique and complex genomes, and understanding their genetic makeup is crucial for beer quality and characteristics.

Deep dives

Researching Yeast Mutations in Serial Re-pitching

A study conducted at the University of Washington focused on the evolution of yeast during cereal re-pitching. The research aimed to understand how mutations occur and how they can affect the traits of yeast cells. The study found that during the re-pitching process, yeast cells underwent various genome changes, including gaining an extra chromosome or rearranging their chromosomes. These changes can have profound consequences for yeast metabolism, affecting metabolite production, growth, and stress tolerance. The researchers also explored potential differences in traits like flocculation, cold tolerance, and ethanol resistance. The study highlighted the value of studying yeast evolution and its implications for industrial applications, health, and the brewing industry in particular.

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