STUDY: Treatment for Traumatic Brain Injuries (Part 1)
Feb 17, 2020
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This podcast explores the use of laser therapy for traumatic brain injuries (TBI). It discusses the different forms and impacts of TBIs, the mechanisms of injury and the potential benefits of laser therapy. The podcast also covers long-term effects and various treatment options for TBIs, including near infrared light therapy. It highlights the challenges of translating positive results from animal studies and emphasizes the importance of correct dosing in laser therapy.
Infrared light therapy has shown promise in treating traumatic brain injuries by stimulating healing mechanisms through cytochrome c oxidase in the mitochondria.
Proper dosing is crucial for infrared light therapy to effectively reach the deeper tissues in the brain and ensure positive outcomes.
Deep dives
Overview of Traumatic Brain Injuries and Treatments
Traumatic brain injuries (TBIs) can result from head impacts, blast forces, or non-contact injuries like whiplash. They can cause a wide range of neurologic, psychiatric, cognitive, and emotional consequences. TBIs are not limited to sports-related injuries but also occur from accidents and falls, affecting millions of people annually. Current treatment options for TBIs focus on managing symptoms rather than reversing the brain damage. Drugs, cognitive rehabilitation, behavioral therapies, and nutritional supplements are used, but their effectiveness varies. Physical exercise has shown promise in improving cognitive function. Another potential avenue for TBI treatment is infrared light therapy, which has demonstrated positive results in animal models. However, translating these findings to humans requires adequate dosing to deliver light to the target tissue.
Mechanisms of Laser Therapy for TBIs
Infrared light therapy works by modulating intracellular mechanisms related to healing, primarily through the stimulation of cytochrome c oxidase in the mitochondria. Low-power lasers and light-emitting diodes (LEDs) have been used successfully in animal models of TBIs and strokes. However, translating these results to humans is challenging due to the differences in tissue density and thickness between animal and human brains. Dose-dependent effects have been observed, with the critical parameter being the dose at the target tissue rather than at the surface. Proper dosing is essential to ensure that the light therapy effectively reaches the deeper tissues in the brain.
Potential of Infrared Light Therapy for TBI Treatment
Although there is limited research on the application of infrared light therapy for TBIs in humans, early studies show promising outcomes in animal models. The therapy's ability to facilitate wound healing, promote muscle repair, and stimulate angiogenesis aligns with addressing the key symptoms of TBIs. However, further research is needed to determine the optimal dose and treatment parameters for human patients. Additionally, it is crucial to consider the unique characteristics of each TBI case, as they vary in severity, symptoms, and progression over time. Infrared light therapy may offer a potential avenue for TBI treatment, but more comprehensive studies are required to establish its efficacy and refine the treatment protocols.
In this two-part series, Dr. Rountree discusses the details from a retrospective case series regarding traumatic brain injury and the results of laser therapy for treatment.