Jeffrey S. Klein, MD, Editor of RadioGraphics, discusses 6 articles from the Novebmer-December 2018 issue of RadioGraphics. ARTICLES DISCUSSED: Breast Cancer Tissue Markers,Genomic Profiling, and Other Prognostic Factors: A Primer for Radiologists., RadioGraphics 2018; 38:1902–1920; 2017 AUA Renal Mass and Localized Renal cancer guidelines:Imaging Implications., RadioGraphics 2018; 38:2021–2033; HIV-related Malignancies and Mimics: Imaging Findings and Management., RadioGraphics 2018; 38:2051–2068; IgG4-related Cardiovascular Disease from the aorta to the Coronary arteries: Multidetector CT and PeT/CT., RadioGraphics 2018; 38:1934–1948; Primary Lung Tumors in children:Radiologic-Pathologic correlation., RadioGraphics 2018; 38:2151–2172; Role of FDG PET/CT in the eighth edition of TnM Staging of non–Small cell Lung cancer., RadioGraphics 2018; 38:2134–2149.